A patient is diagnosed with major depressive disorder. What is the first line treatment option?

The first line treatment for major depressive disorder is typically antidepressant medication. This approach is supported by various clinical guidelines, which indicate that pharmacotherapy can help alleviate the symptoms of depression, including persistent sadness, loss of interest in activities, and difficulties with concentration. Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) are commonly used due to their favorable side effect profile and efficacy in treating moderate to severe depression.

While other options such as cognitive behavioral therapy and psychoeducation can also play important roles in the overall treatment plan for a patient with depression, they are usually considered adjunctive or secondary options rather than first-line treatments. Electroconvulsive therapy is typically reserved for severe cases or when rapid response is necessary due to the acute nature of the disorder or when other treatments have failed. Therefore, antidepressant medication is the primary intervention recommended to initiate treatment and create positive changes in the patient's condition.