Which topical agent is considered the most frequently used for treating partial- and full-thickness thermal injuries?

Silver sulfadiazine, commonly known by the brand name Silvadene, is considered the most frequently used topical agent for treating partial- and full-thickness thermal injuries, such as burns. Its effectiveness lies in its broad-spectrum antibacterial properties, which help prevent infection in compromised skin. This is critical in the management of burns, as patients are at high risk for infection due to the loss of the skin barrier.

In addition to its antimicrobial effects, Silver sulfadiazine promotes wound healing. It facilitates a moist wound environment, which is important for tissue regeneration and minimizes scarring. The application of this agent often leads to improved healing outcomes and is generally well-tolerated by patients.

While other options may have their specific uses in wound care, they do not match the widespread application and clinical preference of Silver sulfadiazine for thermal injuries. For instance, silver nitrate is primarily used for cauterizing and treating smaller wounds, and mafenide acetate is effective but can cause pain and may not be used as frequently. Clotrimazole cream is an antifungal agent and is not indicated for use in thermal injuries, focusing instead on fungal infections. Therefore, Silver sulfadiazine stands out as the go-to choice in the treatment